Cajun Chicken Alfredo Fettuccine

Featured in: Comfort Baking

This dish features tender chicken breasts seasoned with Cajun spices, pan-seared to perfection and sliced thinly. Al dente fettuccine is tossed in a creamy sauce made from butter, garlic, heavy cream, Velveeta, and Parmesan cheeses, with a touch of black and cayenne pepper for warmth. Garnished with fresh parsley, it offers a comforting southern-inspired flavor with a smooth, cheesy texture. Adjust the heat with seasoning or add veggies for extra depth.

Updated on Sun, 23 Nov 2025 16:09:00 GMT
Close-up of a sizzling Cajun Chicken Alfredo Fettuccine Pasta dish, glistening with a creamy Velveeta sauce. Pin
Close-up of a sizzling Cajun Chicken Alfredo Fettuccine Pasta dish, glistening with a creamy Velveeta sauce. | cinnamonnest.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This recipe has become a family favorite; the rich Velveeta sauce paired with the Cajun seasoning transforms a simple pasta dish into something extraordinary.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts 1 ½ tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter 2 cloves garlic minced 1 cup (240 ml) heavy cream 8 oz (225 g) Velveeta cheese cubed ½ cup (50 g) grated Parmesan cheese ½ teaspoon black pepper ¼ teaspoon cayenne pepper (optional for extra heat) Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
Tender chicken tops this comforting Cajun Chicken Alfredo Fettuccine, served in a rich Velveeta cheese sauce. Pin
Tender chicken tops this comforting Cajun Chicken Alfredo Fettuccine, served in a rich Velveeta cheese sauce. | cinnamonnest.com

This dish always brings the whole family to the table for a comforting and flavorful meal.

Required Tools

Large pot Large skillet Knife and cutting board Tongs or pasta fork Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter) Contains wheat (fettuccine) Contains chicken Those with allergies should check ingredient labels for hidden allergens

Nutritional Information

Per serving Calories 670 Total Fat 32 g Carbohydrates 57 g Protein 41 g

Imagine fresh parsley garnishing this flavorful Cajun Chicken Alfredo Fettuccine with its cheesy, creamy sauce. Pin
Imagine fresh parsley garnishing this flavorful Cajun Chicken Alfredo Fettuccine with its cheesy, creamy sauce. | cinnamonnest.com

This Cajun Chicken Alfredo is the perfect blend of spice and creaminess sure to please any pasta lover.

Recipe FAQ

How do I ensure the chicken stays tender?

Cook chicken breasts over medium-high heat until golden and internal temperature reaches 165°F (74°C), then let rest before slicing to retain juices.

Can I use a different type of pasta?

Yes, while fettuccine is ideal for holding the creamy sauce, penne or linguine can also work well with this dish.

How do I adjust the spiciness?

Modify the amount of Cajun seasoning or cayenne pepper to increase or decrease heat according to preference.

What is the best way to melt the Velveeta cheese smoothly?

Stir Velveeta cubes into gently simmering cream, allowing gradual melting with constant stirring to avoid clumping.

Can I prepare components ahead of time?

Chicken can be seasoned and cooked in advance, and sauce can be warmed gently before combining with freshly cooked pasta for best texture.

Cajun Chicken Alfredo Fettuccine

Tender Cajun-seasoned chicken and creamy Velveeta sauce coat fettuccine for a flavorful, comforting meal.

Prep duration
15 min
Cooking duration
25 min
Total duration
40 min

Category Comfort Baking

Difficulty Easy

Origin American (Cajun-inspired)

Yield 4 Servings

Dietary requirements None specified

Ingredients

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Directions

Step 01

Cook pasta: Bring a large pot of salted water to a boil. Add fettuccine and cook until al dente according to package directions. Drain, reserving ½ cup pasta water, and set aside.

Step 02

Prepare chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning on both sides.

Step 03

Cook chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5 to 6 minutes per side until golden and internal temperature reaches 165°F. Remove from skillet, rest for 5 minutes, then slice thinly.

Step 04

Sauté garlic: Reduce skillet heat to medium. Add butter and minced garlic; sauté for 1 minute until fragrant.

Step 05

Prepare sauce base: Pour in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring continuously until fully melted and sauce is smooth.

Step 06

Finish sauce: Incorporate grated Parmesan, black pepper, and cayenne pepper if desired. Stir until sauce is creamy and uniform. Thin sauce with reserved pasta water as needed.

Step 07

Combine pasta with sauce: Add cooked fettuccine to sauce and toss until evenly coated.

Step 08

Serve: Plate pasta and top with sliced Cajun chicken. Garnish with fresh parsley and additional Parmesan if preferred.

Necessary tools

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy information

Review ingredients carefully for potential allergens and consult with a healthcare provider if you're uncertain.
  • Contains milk/dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine)
  • Contains chicken
  • Check labels for hidden allergens

Nutritional information (per serving)

These values are approximate guidelines only and shouldn't replace professional medical advice.
  • Calories: 670
  • Fat: 32 g
  • Carbs: 57 g
  • Protein: 41 g